Academic Qualification
Ph.D. in Chemistry, Stanford University, 2008
B.S. in Chemistry, Peking University, 2004
Teaching Area
Biomaterial
Nanomedicine
Tumor therapy
Immunotherapy
Research Area
Biomaterials and nanomedicine
Nanoscale Biomaterials for Modulation of Tumor Microenvironment
Biomaterials and Immunoengineering
Professional Services
Associate Editor, Biomaterials (2014-present)
Part-time Professor,Children's Hospital of Soochow University
Working Experience
Post-doctoral Scholar, Stanford University, 2009
Professor, Soochow University, 2009-present
Academic Publication (selected)
1. Chenya Wang, Liping Zhong, Jiachen Xu, Qi Zhuang, Fei Gong, Xiaojing Chen, Huiquan Tao, Cong Hu, Fuquan Huang, Nailin Yang, Junyan Li, Qi Zhao, Xinjun Sun, Yu Huo, Qian Chen, Yongxiang Zhao*, Rui Peng* , Zhuang Liu*.“Oncolytic mineralized bacteria as potent locally administered immunotherapeutics” Nat. Biomed. Eng., 8, 561-578 (2024)
2. Wenjun Zhu, Ting Wei, Yuchun Xu, Qiutong Jin, Yu Chao, Jiaqi Lu, Jun Xu, Jiafei Zhu, Xiaoying Yan, Muchao Chen, Qian Chen *, Zhuang Liu*. “Non-invasive transdermal delivery of biomacromolecules with fluorocarbon-modified chitosan for melanoma immunotherapy and viral vaccines” Nature Communications, 15, 820 (2024)
3. Yu Chao , Zhuang Liu*. “Biomaterials tools to modulate the tumour microenvironment in immunotherapy” Nature Reviews Bioengineering, 1, 125-138 (2023)
4. Jun Zhou, Maoyi Li, Qiufang Chen, Xinjie Li, Linfu Chen, Ziliang Dong, Wenjun Zhu, Yang Yang, Zhuang Liu* & Qian Chen*. “Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery” Nat.Commun., 13, 3432 (2022)
5. Yujie Zhu, Zhijuan Yang, Zijian Pan, Yu Hao, Chunjie Wang, Ziliang Dong, Quguang Li, Yikai Han, Longlong Tian, Liangzhu Feng*, Zhuang Liu*. “Metallo-alginate hydrogel can potentiate microwave tumor ablation for synergistic cancer treatment” Science Advances, 8, 31, 5285 (2022)
6. Han Zhang, Wenjun Zhu, Qiutong Jin, Feng Pan, Jiafei Zhu, Yanbin Liu, Linfu Chen, Jingjing Shen, Yang Yang*, Qian Chen*, and Zhuang Liu*. “Inhalable nanocatchers for SARS-CoV-2 inhibition” Proc. Natl. Acad. Sci. U.S.A., 118(29): e2102957118 (2021)
7. Zhijuan Yang, Yujie Zhu, Ziliang Dong, Wei Li, Nailin Yang, Xianwen Wang, Liangzhu Feng* & Zhuang Liu*. “Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses” Nat. Commun., 12, 4299 (2021)
8. Jun Xu, Jia Lv, Qi Zhuang, Zongjin Yang, Zhiqin Cao, Ligeng Xu, Pei Pei, Chenya Wang, Hanfei Wu, Ziliang Dong, Yu Chao, Chao Wang, Kai Yang, Rui Peng*, Yiyun Cheng* and Zhuang Liu*.” A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy” Nat. Nanotechnol., 15, 1043-1052 (2020).
9. Xuan Yi, Hailin Zhou, Yu Chao, Saisai Xiong, Jing Zhong, Zhifang Chai, Kai Yang*, and Zhuang Liu*. “Bacteria-triggered tumor-specific thrombosis to enable potent photothermal immunotherapy of cancer” Sci. Adv., 6(33): eaba3546 (2020).
10. Fei Gong, Liang Cheng*, Nailin Yang, Yuehan Gong, Yanwen Ni, Shang Bai, Xianwen Wang, Muchao Chen, Qian Chen, Zhuang Liu*. "Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy" Nat. Commun., 11, 3712 (2020).
11. Lele Sun, Fengyun Shen, Jun Xu, Xiao Han, Chunhai Fan, Zhuang Liu*. ”DNA-Edited Ligand Positioning on Red Blood Cells to Enable Optimized T Cell Activation for Adoptive Immunotherapy” Angew. Chem. Int. Ed., 59, 2-14 (2020).
12. Yu Chao, Chao Liang, Huiquan Tao, Yaran Du, Di Wu, Ziliang Dong, Qiutong Jin, Guobin Chen, Jun Xu, Zhisheng Xiao, Qian Chen, Chao Wang, Jian Chen and Zhuang Liu*.“Localized cock-tail chemo-immunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.” Sci. Adv., 6(10), eaaz4204 (2020).
13. Ziliang Dong, Liangzhu Feng*, Yu Hao, Quguang Li, Muchao Chen, Zhijuan Yang, He Zhao, ZhuangLiu*. “Synthesis of CaCO3 based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress.” Chem, 6,1391-1407 (2020).
14. Jingjing Liu, Min Wu, Yutong Pan, Yukun Duan, Ziliang Dong, Yu Chao, Zhuang Liu*, Bin Liu*. “Biodegradable Nanoscale Coordination Polymers for Targeted Tumor Combination Therapy with Oxidative Stress Amplification.” Adv. Funct. Mater., 30, 1908865 (2020).
15. Lin Zhang, Jinhua Zhou, Lvzhong Hu, Xiao Han, Xinwei Zou, Qian Chen, Youguo Chen*, Zhuang Liu*, Chao Wang*. “In Situ Formed Fibrin Scaffold with Cyclophosphamide to Synergize with Immune Checkpoint Blockade for Inhibition of Cancer Recurrence after Surgery.” Adv. Funct. Mater., 30(7), 1906922 (2020).
16. Xiao Han, Shufang Shen, Qin Fan, Guojun Chen, Edikan Archibong, Gianpietro Dotti, Zhuang Liu*, Zhen Gu*, and Chao Wang*. “Red Blood Cell–Derived Nanoerythrosome for Antigen Delivery with Enhanced Cancer Immunotherapy.” Sci. Adv., 5 (10), eaaw6870 (2019).
17. Qian Chen*, Muchao Chen, and Zhuang Liu*. “Local Biomaterials-Assisted Cancer Immunotherapy to Trigger Systemic Antitumor Responses.” Chem. Soc. Rev., 48 (22), 5506–26 (2019).
18. Longlong Tian, Yaxing Wang, Lele Sun, Kai Yang, Shuao Wang, Zhuang Liu*. “Cerenkov Luminescence-Induced NO Release from 32P-Labeled ZnFe(CN)5NO Nanosheets to Enhance Radioisotope-Immunotherapy” Matter,1(4),1061-76 (2019).
19. Yu Chao, Qian Chen*, Zhuang Liu*. “Smart Injectable Hydrogels for Cancer Immunotherapy” Adv. Funct. Mater.,1902785 (2019).
20. Liang Cheng*, Xianwen Wang, Fei Gong, Teng Liu, Zhuang Liu*. “2D Nanomaterials for Cancer Theranostic Applications” Adv. Mater., 2019, 1902333 (2019).
21. Fei Gong, Liang Cheng*, Nailin Yang, Oshra Betzer, Liangzhu Feng, Qiang Zhou, Yonggang Li, Ruihua Chen, Rachela Popovtzer and Zhuang Liu*. “Ultrasmall Oxygen-Deficient Bimetallic Oxide MnWOX Nanoparticles for Depletion of Endogenous GSH and Enhanced Sonodynamic Cancer Therapy” Adv. Mater., (31)23, 1900730 (2019).
22. Yu Chao, Ligeng Xu, Chao Liang, Liangzhu Feng, Jun Xu, Ziliang Dong, Longlong Tian, Xuan Yi, Kai Yang* and Zhuang Liu*. "Combined Local Immunostimulatory Radioisotope Therapy and Systemic Immune Checkpoint Blockade Imparts Potent Antitumour Responses" Nat. Biomed. Eng., 2, 611-621(2018).
23. Guangbao Yang, Ligeng Xu, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng, and Zhuang Liu*. “Hollow MnO2 as A Tumor-microenvironment-responsive Biodegradable Nano-platform for Combination Therapy Favoring Antitumor Immune Responses” Nat. Commun., 8, 902 (2017).
24. Qian Chen, Chao Liang, Xiaoqi Sun, Jiawen Chen, Zhijuan Yang, He Zhao, Liangzhu Feng, and Zhuang Liu*. “H2O2-responsive Liposomal Nanoprobe for Photoacoustic Inflammation Imaging and Tumor Theranostics via In Vivo Chromogenic Assay” Proc. Natl. Acad. Sci. U.S.A., 114(21), 5343-5348 (2017).
25. Qian Chen, Ligeng Xu, ChaoLiang, Chao Wang, Rui Peng, and Zhuang Liu*. “Photothermal Therapy with Immune-adjuvant Nanoparticles Together with Checkpoint Blockade for Effective Cancer Immunotherapy” Nat. Commun., 7, 13193 (2016).
Research Grants
2016.01 -2020.12, Exploring Functional Nanomaterials in Novel Tumor Therapeutics（NSFC）
2017.10 -2020.09, Inorganic nanoreactors and biomimetic carriers for tumor radiation therapy research
（NSFC）
2020.01 -2024.12, Magnetic polarization photoacoustic imaging system and its application to “background-free” in vivo imaging analysis（NSFC）
2021.01 -2025.12, Design and construction of novel biomineralized materials and exploration of their application in hepatocellular carcinoma interventional therapy （NSFC）
2021.12 -2024.12,Development of NIR-II Fluorescent Imaging Agents for Biomedical Applications (National Key R&D Program, Ministry of Science and Technology of China)
2024.01 -2028.12 Cross-disciplinary research on immune engineering targeting the tumor microenvironment（NSFC）
Patents
1.CN patent，ZL2022104691696，Active metal microspheres, composite embolic agents based on active metal microspheres, and their applications
2.EP patent，EP3643315B1,Composition comprising catalase, preparation method and use thereof and method for killing tumor cells Composition comprising catalase, preparation method and use thereof and method for killing tumor cells
3.U.S. patent，US11173220B2 COMPOSITION COMPRISING CATALASE, PREPARATION METHOD AND USE THEREOF AND METHOD FOR KILLING TUMOR CELL COMPOSITION COMPRISING CATALASE, PREPARATION METHOD AND USE THEREOF AND METHOD FOR KILLING TUMOR CELL
4.CN patent，ZL2017104675955，A composition comprising catalase and its use
5.CN patent，ZL2020100636385，The application of fluoro-compound-modified chitosan in the preparation of transdermal drug delivery formulations
6.CN patent，ZL2020100636366，The application of fluoro-compound-modified cationic polymers in the preparation of mucosal drug delivery systems
7.CN patent，ZL2020100636205，The application of fluoro-compound-modified cationic polymers in the preparation of ocular pharmaceuticals
8.CN patent，ZL2021100143823，Bioluminescent engineered bacterial compositions, their preparation methods, and applications
9.CN patent，ZL2021112288679，A nano-capture agent for inhibiting SARS-CoV-2
10.CN patent，ZL2021114060116，A pharmaceutical formulation, its preparation method, and application
Professional Certification and Awards
2024 “BEST EDITOR AWARD”(Nano Research)
2023 “Suzhou Overseas Chinese Youth Pioneer” Award
2022 ScienceTalk - Life Sciences New Force of the Year Award
2021 Xplorer Prize, Executive Committee of Xplorer Prize, China
2020 The 16th China Youth Science and Technology Award,China Association for Science and Technology,China
2019 CSC-RSC Young Chemist Award, Chinese Chemical Society & the Royal Society of Chemistry,China & UK
2019 Fellow of American Institute for Medical and Biological Engineering
2018 Periodic Table of Younger Chemists (IUPAC)
2018 Nano Research Young Innovator Awards
2018 Changjiang Distinguished Professor
2017 Biomaterials Science lectureship, Royal Society of Chemistry (RSC)
2017 Jiangsu Science and Technology Award, China
2015 NFSC Distinguished Young Scholar Award
2015 Fellow, Royal Society of Chemistry (RSC)
2014 Young Chemist Award, Chinese Chemical Society, China
2013 Asian Rising Stars, 15th Asian Chemistry Congress, Singapore
2012 SCOPUS Young Researcher Award, China
2008 MRS Silver Award, Materials Research Society, USA
Professional Society Membership
Fellow, Royal Society of Chemistry (FRSC)
Fellow, American Institute for Medical and Biological Engineering (AIMBE)
