Academic Qualification

Ph.D. in Chemistry, Stanford University, 2008

B.S. in Chemistry, Peking University, 2004

Teaching Area

Biomaterial

Nanomedicine

Tumor therapy

Immunotherapy

Research Area

Biomaterials and nanomedicine

Nanoscale Biomaterials for Modulation of Tumor Microenvironment

Biomaterials and Immunoengineering

Professional Services

Associate Editor, Biomaterials (2014-present)

Part-time Professor,Children's Hospital of Soochow University

Working Experience

Post-doctoral Scholar, Stanford University, 2009

Professor, Soochow University, 2009-present

Academic Publication (selected)

1.        Chenya Wang, Liping Zhong, Jiachen Xu, Qi Zhuang, Fei Gong, Xiaojing Chen, Huiquan Tao, Cong Hu, Fuquan Huang, Nailin Yang, Junyan Li, Qi Zhao, Xinjun Sun, Yu Huo, Qian Chen, Yongxiang Zhao*, Rui Peng* , Zhuang Liu*.“Oncolytic mineralized bacteria as potent locally administered immunotherapeutics” Nat. Biomed. Eng., 8, 561-578 (2024)

2.        Wenjun Zhu, Ting Wei, Yuchun Xu, Qiutong Jin, Yu Chao, Jiaqi Lu, Jun Xu, Jiafei Zhu, Xiaoying Yan, Muchao Chen, Qian Chen *, Zhuang Liu*. “Non-invasive transdermal delivery of biomacromolecules with fluorocarbon-modified chitosan for melanoma immunotherapy and viral vaccines” Nature Communications, 15, 820 (2024)

3.        Yu Chao , Zhuang Liu*. “Biomaterials tools to modulate the tumour microenvironment in immunotherapy” Nature Reviews Bioengineering, 1, 125-138 (2023)

4.        Jun Zhou, Maoyi Li, Qiufang Chen, Xinjie Li, Linfu Chen, Ziliang Dong, Wenjun Zhu, Yang Yang, Zhuang Liu* & Qian Chen*. “Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery” Nat.Commun., 13, 3432 (2022)

5.        Yujie Zhu, Zhijuan Yang, Zijian Pan, Yu Hao, Chunjie Wang, Ziliang Dong, Quguang Li, Yikai Han, Longlong Tian, Liangzhu Feng*, Zhuang Liu*. “Metallo-alginate hydrogel can potentiate microwave tumor ablation for synergistic cancer treatment” Science Advances, 8, 31, 5285 (2022)

6.        Han Zhang, Wenjun Zhu, Qiutong Jin, Feng Pan, Jiafei Zhu, Yanbin Liu, Linfu Chen, Jingjing Shen, Yang Yang*, Qian Chen*, and Zhuang Liu*. “Inhalable nanocatchers for SARS-CoV-2 inhibition” Proc. Natl. Acad. Sci. U.S.A., 118(29): e2102957118 (2021)

7.        Zhijuan Yang, Yujie Zhu, Ziliang Dong, Wei Li, Nailin Yang, Xianwen Wang, Liangzhu Feng* & Zhuang Liu*. “Tumor-killing nanoreactors fueled by tumor debris can enhance radiofrequency ablation therapy and boost antitumor immune responses” Nat. Commun., 12, 4299 (2021)

8.        Jun Xu, Jia Lv, Qi Zhuang, Zongjin Yang, Zhiqin Cao, Ligeng Xu, Pei Pei, Chenya Wang, Hanfei Wu, Ziliang Dong, Yu Chao, Chao Wang, Kai Yang, Rui Peng*, Yiyun Cheng* and Zhuang Liu*.” A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy” Nat. Nanotechnol., 15, 1043-1052 (2020).

9.        Xuan Yi, Hailin Zhou, Yu Chao, Saisai Xiong, Jing Zhong, Zhifang Chai, Kai Yang*, and Zhuang Liu*. “Bacteria-triggered tumor-specific thrombosis to enable potent photothermal immunotherapy of cancer” Sci. Adv., 6(33): eaba3546 (2020).

10.    Fei Gong, Liang Cheng*, Nailin Yang, Yuehan Gong, Yanwen Ni, Shang Bai, Xianwen Wang, Muchao Chen, Qian Chen, Zhuang Liu*. "Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy" Nat. Commun., 11, 3712 (2020).

11.    Lele Sun, Fengyun Shen, Jun Xu, Xiao Han, Chunhai Fan, Zhuang Liu*. ”DNA-Edited Ligand Positioning on Red Blood Cells to Enable Optimized T Cell Activation for Adoptive Immunotherapy” Angew. Chem. Int. Ed., 59, 2-14 (2020).

12.    Yu Chao, Chao Liang, Huiquan Tao, Yaran Du, Di Wu, Ziliang Dong, Qiutong Jin, Guobin Chen, Jun Xu, Zhisheng Xiao, Qian Chen, Chao Wang, Jian Chen and Zhuang Liu*.“Localized cock-tail chemo-immunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.” Sci. Adv., 6(10), eaaz4204 (2020).

13.    Ziliang Dong, Liangzhu Feng*, Yu Hao, Quguang Li, Muchao Chen, Zhijuan Yang, He Zhao, ZhuangLiu*. “Synthesis of CaCO3 based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress.” Chem, 6,1391-1407 (2020).

14.    Jingjing Liu, Min Wu, Yutong Pan, Yukun Duan, Ziliang Dong, Yu Chao, Zhuang Liu*, Bin Liu*. “Biodegradable Nanoscale Coordination Polymers for Targeted Tumor Combination Therapy with Oxidative Stress Amplification.” Adv. Funct. Mater., 30, 1908865 (2020).

15.    Lin Zhang, Jinhua Zhou, Lvzhong Hu, Xiao Han, Xinwei Zou, Qian Chen, Youguo Chen*, Zhuang Liu*, Chao Wang*. “In Situ Formed Fibrin Scaffold with Cyclophosphamide to Synergize with Immune Checkpoint Blockade for Inhibition of Cancer Recurrence after Surgery.” Adv. Funct. Mater., 30(7), 1906922 (2020).

16.    Xiao Han, Shufang Shen, Qin Fan, Guojun Chen, Edikan Archibong, Gianpietro Dotti, Zhuang Liu*, Zhen Gu*, and Chao Wang*. “Red Blood Cell–Derived Nanoerythrosome for Antigen Delivery with Enhanced Cancer Immunotherapy.” Sci. Adv., 5 (10), eaaw6870 (2019).

17.    Qian Chen*, Muchao Chen, and Zhuang Liu*.  “Local Biomaterials-Assisted Cancer Immunotherapy to Trigger Systemic Antitumor Responses.” Chem. Soc. Rev., 48 (22), 5506–26 (2019).

18.    Longlong Tian, Yaxing Wang, Lele Sun, Kai Yang, Shuao Wang, Zhuang Liu*. “Cerenkov Luminescence-Induced NO Release from 32P-Labeled ZnFe(CN)5NO Nanosheets to Enhance Radioisotope-Immunotherapy” Matter,1(4),1061-76 (2019).

19.    Yu Chao, Qian Chen*, Zhuang Liu*. “Smart Injectable Hydrogels for Cancer Immunotherapy” Adv. Funct. Mater.,1902785 (2019).

20.    Liang Cheng*, Xianwen Wang, Fei Gong, Teng Liu, Zhuang Liu*. “2D Nanomaterials for Cancer Theranostic Applications” Adv. Mater., 2019, 1902333 (2019).

21.    Fei Gong, Liang Cheng*, Nailin Yang, Oshra Betzer, Liangzhu Feng, Qiang Zhou, Yonggang Li, Ruihua Chen, Rachela Popovtzer and Zhuang Liu*. “Ultrasmall Oxygen-Deficient Bimetallic Oxide MnWOX Nanoparticles for Depletion of Endogenous GSH and Enhanced Sonodynamic Cancer Therapy” Adv. Mater., (31)23, 1900730 (2019).

22.    Yu Chao, Ligeng Xu, Chao Liang, Liangzhu Feng, Jun Xu, Ziliang Dong, Longlong Tian, Xuan Yi, Kai Yang* and Zhuang Liu*. "Combined Local Immunostimulatory Radioisotope Therapy and Systemic Immune Checkpoint Blockade Imparts Potent Antitumour Responses" Nat. Biomed. Eng., 2, 611-621(2018).

23.     Guangbao Yang, Ligeng Xu, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng, and Zhuang Liu*. “Hollow MnO2 as A Tumor-microenvironment-responsive Biodegradable Nano-platform for Combination Therapy Favoring Antitumor Immune Responses” Nat. Commun., 8, 902 (2017).

24.    Qian Chen, Chao Liang, Xiaoqi Sun, Jiawen Chen, Zhijuan Yang, He Zhao, Liangzhu Feng, and Zhuang Liu*. “H2O2-responsive Liposomal Nanoprobe for Photoacoustic Inflammation Imaging and Tumor Theranostics via In Vivo Chromogenic Assay” Proc. Natl. Acad. Sci. U.S.A., 114(21), 5343-5348 (2017).

25.     Qian Chen, Ligeng Xu, ChaoLiang, Chao Wang, Rui Peng, and Zhuang Liu*. “Photothermal Therapy with Immune-adjuvant Nanoparticles Together with Checkpoint Blockade for Effective Cancer Immunotherapy” Nat. Commun., 7, 13193 (2016).

Research Grants

2016.01 -2020.12, Exploring Functional Nanomaterials in Novel Tumor Therapeutics（NSFC）

2017.10 -2020.09, Inorganic nanoreactors and biomimetic carriers for tumor radiation therapy research

（NSFC）

2020.01 -2024.12, Magnetic polarization photoacoustic imaging system and its application to “background-free” in vivo imaging analysis（NSFC）

2021.01 -2025.12, Design and construction of novel biomineralized materials and exploration of their application in hepatocellular carcinoma interventional therapy （NSFC）

2021.12 -2024.12,Development of NIR-II Fluorescent Imaging Agents for Biomedical Applications (National Key R&D Program, Ministry of Science and Technology of China)

2024.01 -2028.12 Cross-disciplinary research on immune engineering targeting the tumor microenvironment（NSFC）

Patents

1.CN patent，ZL2022104691696，Active metal microspheres, composite embolic agents based on active metal microspheres, and their applications

2.EP patent，EP3643315B1,Composition comprising catalase, preparation method and use thereof and method for killing tumor cells        Composition comprising catalase, preparation method and use thereof and method for killing tumor cells

3.U.S. patent，US11173220B2 COMPOSITION COMPRISING CATALASE, PREPARATION METHOD AND USE THEREOF AND METHOD FOR KILLING TUMOR CELL   COMPOSITION COMPRISING CATALASE, PREPARATION METHOD AND USE THEREOF AND METHOD FOR KILLING TUMOR CELL

4.CN patent，ZL2017104675955，A composition comprising catalase and its use

5.CN patent，ZL2020100636385，The application of fluoro-compound-modified chitosan in the preparation of transdermal drug delivery formulations

6.CN patent，ZL2020100636366，The application of fluoro-compound-modified cationic polymers in the preparation of mucosal drug delivery systems

7.CN patent，ZL2020100636205，The application of fluoro-compound-modified cationic polymers in the preparation of ocular pharmaceuticals

8.CN patent，ZL2021100143823，Bioluminescent engineered bacterial compositions, their preparation methods, and applications

9.CN patent，ZL2021112288679，A nano-capture agent for inhibiting SARS-CoV-2

10.CN patent，ZL2021114060116，A pharmaceutical formulation, its preparation method, and application

Professional Certification and Awards

2024  “BEST EDITOR AWARD”(Nano Research)

2023  “Suzhou Overseas Chinese Youth Pioneer” Award

2022  ScienceTalk - Life Sciences New Force of the Year Award

2021  Xplorer Prize, Executive Committee of Xplorer Prize, China

2020  The 16th China Youth Science and Technology Award,China Association for Science and Technology,China

2019  CSC-RSC Young Chemist Award, Chinese Chemical Society & the Royal Society of Chemistry,China & UK

2019  Fellow of American Institute for Medical and Biological Engineering

2018  Periodic Table of Younger Chemists (IUPAC)

2018  Nano Research Young Innovator Awards

2018  Changjiang Distinguished Professor

2017  Biomaterials Science lectureship, Royal Society of Chemistry (RSC)

2017  Jiangsu Science and Technology Award, China

2015  NFSC Distinguished Young Scholar Award

2015  Fellow, Royal Society of Chemistry (RSC)

2014  Young Chemist Award, Chinese Chemical Society, China

2013  Asian Rising Stars, 15th Asian Chemistry Congress, Singapore

2012  SCOPUS Young Researcher Award, China

2008  MRS Silver Award, Materials Research Society, USA

Professional Society Membership

Fellow, Royal Society of Chemistry (FRSC)

Fellow, American Institute for Medical and Biological Engineering (AIMBE)