Academic Qualification
Ph.D. in Soochow University
Master in Anhui Normal University
Bachelor in Anhui Polytechnic University
Teaching Area
Biomaterials
Nanomaterials-Synthesis and Characterization
Research Area
Functional micro/nano biomaterials
Novel cancer therapy
Biological effects
Anti-inflammatory/antibacterial
Working Experience
Jan. 2023 ~ present, Professor, Department of Materials Science and Engineering, Faculty of Innovation Engineering, Macau University of Science and Technology, Macao, China
Nov. 2019 ~ present, Professor (Principal Investigator), Institute of Functional Nano & Soft Material (FUNSOM), Soochow University, Suzhou, Jiangsu, China
Jul. 2017 ~ Oct. 2019, Research Professor, Institute of Functional Nano & Soft Material (FUNSOM), Soochow University, Suzhou, Jiangsu, China
Aug. 2015 ~ Aug. 2016, Visiting Scholar, University of Wisconsin-Madison
Jul. 2014 ~ Jun. 2017, Associate Professor, Institute of Functional Nano & Soft Material (FUNSOM), Soochow University, Suzhou, Jiangsu, China
Aug. 2012 ~ Jun. 2014, Lecturer, Institute of Functional Nano & Soft Material (FUNSOM), Soochow University, Suzhou, Jiangsu, China
Research Experiences and Accomplishments
Dr. Cheng’s work has focused on the preparation of functional nanostructured inorganic materials and their applications in nanomedicine. Over the past several years, he has developed three types of functional biomaterials for imaging-guided cancer photo-therapy and combined therapy. It has been shown that such novel strategies offer obvious advantages in realizing precise treatment of cancer and improving the specificity of tumor therapy.
Dr. Cheng has authored a total of over 260 peer-reviewed SCI papers, including Chem Rev., Chem. Soc. Rev., Nat. Commun., Chem, J. Am. Chem. Soc., Adv. Mater., Angew. Chem. Int. Ed., Adv. Funct. Mater., Natl. Sci. Rev., Nano Today, which have been cited by others over 30,423 times (H-index = 92). Dr. Cheng was listed as one of the ‘Highly Cited Researchers (Materials Science)’ by Clarivate Analytics in 2017-2023and ‘China’s Highly Cited Researchers (Materials Science)’ in 2017-2023. Dr. Cheng served as the deputy editor of Journal of Nanobiotechnology (IF=10.6, Q1). He was supported by key projects and general projects of the National Natural Science Foundation of China's Joint Fund for Regional Development, as well as outstanding young people in Jiangsu Province and outstanding young people in Jiangsu Province. He was also selected as the Young ChangJiang Scholar of the Ministry of Education, Tang Scholar of Suzhou University, Soochow Scholar of Suzhou University, and the Jiangsu 333 Talent Project. Now, based on the previous studies of functional nanomaterials for in vivo multimodal imaging and tumor therapy, Dr. Cheng wants to develop bioactive functional nanomaterials for enhanced cancer treatment. The goal is to find a few kinds of bioactive theranostic agents with low toxicity and high cancer therapeutic performances.
Representative papers in recent 3 years (2022-2024)
1. Yuqi Yang, Huazheng Liang, Chun Tang, Yuan Cheng*, Liang Cheng*, Exploration of Ultrasound-Sensitive Biomaterials in Cancer Theranostics, Advanced Functional Materials, 2024, 2313454.
2. Yujie Lu, Youdong Chen, Guanghui Hou*, Huali Lei, Lin Liu, Xuan Huang, Shumin Sun, Luyao Liu, Xiyu Liu, Jintong Na, Yongxiang Zhao, Liang Cheng*, Liping Zhong*, Zinc-Iron Bimetallic Peroxides Modulate the Tumor Stromal Microenvironment and Enhance Cell Immunogenicity for Enhanced Breast Cancer Immunotherapy Therapy, ACS Nano, 2024, DOI. org/10.1021/acsnano.3c12615.
3. Gang Wang, Jingrui Li, Li Wang, Yuqi Yang, Jie Wu, Wei Tang, Huali Lei, Liang Cheng*, Manganese-Doped Potassium Chloride Nanoelectrodes to Potentiate Electrochemical Immunotherapy, ACS Nano, 2024, DOI. org/10.1021/acsnano.4c01132.
4. Wei Tang, Jie Wu, Li Wang*, Kailu Wei, Zifan Pei, Fei Gong, Linfu Chen, Zhihui Han, Yuqi Yang, Yizhi Dai, Xiaoliang Cui, and Liang Cheng*, Bioactive Layered Double Hydroxides for Synergistic Sonodynamic/Cuproptosis Anticancer Therapy with Elicitation of the Immune Response, ACS Nano, 2024, DOI. org/10.1021/acsnano.3c11818.
5. Huali Lei, Quguang Li, Guangqiang Li, Tianyi Wang, Xinjing Lv, Zifan Pei, Xiang Gao, Nailin Yang, Fei Gong, Yuqi Yang, Guanghui Hou, Minjang Chen, Jiansong Ji*, Zhuang Liu*, and Liang Cheng*, Manganese molybdate nanodots with dual amplification of STING activation for "cycle" treatment of metalloimmunotherapy, Bioactive Materials 2024, 31, 53-62.
6. Xiaoliang Cui, Li Wang, Xiang Gao, Jie Wu, Tian Hu, Jun Zhang, Xiaozhong Zhou*, Ke-Qin Zhang*, Liang Cheng*, Self-assembled silk fibroin injectable hydrogels based on layered double hydroxides for spinal cord injury repair, Matter, 2024, 7, 620-639.
2023
1. Zifan Pei, Huali Lei, Liang Cheng*, Bioactive inorganic nanomaterials for cancer theranostics, Chemical Society Reviews, 2023,52, 2031-2081.
2. Zifan Pei, Huali Lei, Jie Wu, Wei Tang, Kailu Wei, Li Wang, Fei Gong, Nailin Yang, Lin Liu, Yuqi Yang, Liang Cheng*, Bioactive Vanadium Disulfide Nanostructure with “Dual” Antitumor Effects of Vanadate and Gas for Immune-Checkpoint Blockade-Enhanced Cancer Immunotherapy, ACS Nano, 2023, 17, 17, 17105-17121.
3. Kailu Wei, Fei Gong*, Jie Wu, Wei Tang, Fan Liao, Zhihui Han, Zifan Pei, Huali Lei, Li Wang, Mingwang Shao, Zhuang Liu, Liang Cheng*, Orally Administered Silicon Hydrogen Nanomaterials as Target Therapy to Treat Intestinal Diseases, ACS Nano, 2023, 17, 21, 21539-21552.
4. Wang Li, Mao Zhuo, Wu Jie, Cui Xiaoliang, Wang Yuanjie, Yang Nailin, Ge Jun, Lei Huali, Han Zhihui, Tang Wei, Guan Shanyue, Liang Cheng*, Engineering layered double hydroxide-based sonocatalysts for enhanced sonodynamic-immunotherapy, Nano Today, 2023, 49, 101782.
5. Wu Jie, Wang Li*, Tang, Wei, Cui, Xiaoliang, Wei, Kailu, Cheng, Shuning, Pei, Zifan, Lei, Huali, Zhuang Liu, Cheng Liang*, Amplifying oxidation stress and T-cell activation by bioactive layered double hydroxide sonosensitizers for enhanced cancer immunotherapy, Materials Today, 2023, 68, 164-176.
6. Nailin Yang, Xingwei Sun, Yangkai Zhou, Xiaoyuan Yang, Jiaxi You, Zepeng Yu, Jun Ge, Fei Gong, Zhisheng Xiao, Yong Jin*, Zhuang Liu*, Liang Cheng*, Liquid metal microspheres with an eddy-thermal effect for magnetic hyperthermia-enhanced cancer embolization-immunotherapy, Science Bulletin, 2023, 68, 16, 1772-1783.
7. Fei Gong, Nailin Yang, Jiachen Xu, Xiaoyuan Yang, Kailu Wei, Linqian Hou, Bo Liu, He Zhao, Zhuang Liu, Liang Cheng*, Calcium Hydride-Based Dressing to Promote Wound Healing, Advanced Healthcare Materials, 2023, 12, 2, 2201771.
8. Jun Ge, Nailin Yang, Yuqi Yang, Hao Yu, Xiaoyuan Yang, Yingjie Wang, Tianyi Wang, Shuning Cheng, Yuanjie Wang, Zhihui Han, Yun Teng, Jun Zou*, Huilin Yang*, Liang Cheng*, The combination of eddy thermal effect of biodegradable magnesium with immune checkpoint blockade shows enhanced efficacy against osteosarcoma, Bioactive materials, 2023, 25, 73-85.
9. Tianyi Wang, Huali Lei, Xiang Li, Nailin Yang, Cheng Ma, Guangqiang Li, Xiang Gao, Jun Ge, Zhuang Liu, Liang Cheng*, Gang Chen*, Magnetic Targeting Nanocarriers Combined with Focusing Ultrasound for Enhanced Intracerebral Hemorrhage Therapy, Small, 2023, 19, 2206982.
10. Shuning Cheng, Lin Chen, Fei Gong, Xiaoyuan Yang, Zhihui Han, Yuanjie Wang, Jun Ge, Xiang Gao, Yuting Li, Xiaoyan Zhong, Li Wang, Huali Lei, Xiaozhong Zhou, Zengli Zhang, Liang Cheng*, PtCu Nanosonosensitizers with Inflammatory Microenvironment Regulation for Enhanced Sonodynamic Bacterial Elimination and Tissue Repair, Advanced Functional Materials, 2023, 33, 2212489.
11. Huali Lei, Guanghui Hou, Minjiang Chen, Jiansong Ji*, Liang Cheng*, Biological effects of metal-based nanomaterials for tumor metalloimmunotherapy, Nano Today, 2023, 53, 102033.
12. Huali Lei, Quguang Li, Zifan Pei, Lin Liu, Nailin Yang, Liang Cheng*, Nonferrous Ferroptosis Inducer Manganese Molybdate Nanoparticles to Enhance Tumor Immunotherapy, Small, 2023,19, 2303438.
13. Huali Lei, Zifan Pei, Chenyu Jiang, Liang Cheng*, Recent progress of metal-based nanomaterials with anti-tumor biological effects for enhanced cancer therapy, Exploration, 10.1002/EXP.20220001.
14. Du Yan, Huo Qi Yang, Zhihui Han, Linqian Hou, Bixiao Cui, Kevin Fan, Yongkang Qiu, Zhao Chen, Wenpeng Huang, Jie Lu, Liang Cheng*, Weibo Cai*, Lei Kang*, Ultrasmall iron-gallic acid coordination polymer nanodots with antioxidative neuroprotection for PET/MR imaging-guided ischemia stroke therapy, Exploration, 2023m3, 20220041.
15. Zekun Wang, Pu Zhang, Chenyang Yin, Yuqing Li, Ziyu Liao, Chenhao Yang, Hang Liu, Weiyun Wang, Cundong Fan, Dongdong Sun*, and Liang Cheng*, Antibiotic-Derived Carbon-Nanodot-Decorated Hydrogel for Reactive Oxygen Species-Enhanced Anti-Infection Through Biofilm Damage, Advanced Functional Materials, 2023,23, 2300341.
16. Caiting Deng, Meichen Zheng, Shupeng Han, Yuanjie Wang, Jingqi Xin, Omer Aras, Liang Cheng*, and Feifei An*, GSH-Activated Porphyrin Sonosensitizer Prodrug for Fluorescence Imaging-Guided Cancer Sonodynamic Therapy, Advanced Functional Materials, 2023, 2300348.
